Publishchemidea, 2014 No: 11

Submitted: Friday, April 18th, 2014

Title of the idea: A New ligand for CBS reduction
Author of the idea: Ramesha
Email of the author
Key words for search: CBS, ligand, reduction
Explain briefly the idea

CBS reduction is known to give > 98% enantiomeric excess in keto reductions. A New Ligand is proposed which is easy to make. This has 2 additional coordinating heteroatoms. This may be a better ligand?

Why do you think this idea will work? It has 2 more coordinating hetero atoms in the active site. This might deliver better result. There is also 2 chiral centres which might be better.
Do you have any experimental proof? No
Literature reference E. J. Corey, J. O. Link, J. Am. Chem. Soc., 1992, 114, 1906-1908
Where it is useful? Academic
Do you plan to work on this idea in near future? Yes
Interested in collaboration? Yes
Nature of idea: Theoretical/experimental
Youtube link:
Download article as PDF

Leave a Reply

You must be logged in to post a comment.