Publishchemidea, 2019 No: 23

Submitted: Wednesday, December 25th, 2019

Title of the idea: Synthesis of Pyrazoline derivatives
Author of the idea: Prachi Raikar
Email of the author
Key words for search: Pyrazoline derivatives
Explain briefly the idea

Acetophenone and 4-methoxybenzaldehyde were reacted in presence of sodium hydroxide with ethanol as the solvent leading to the formation of chalcones. (1) These chalcones were reacted hydrazine hydrate which formed the new cyclized product. (2). This was further reacted with ethylchloroacetate to give (3) product which was reacted with hydrazine hydrate to give (4).This product was reacted with different aromatic aldehydes to give final pyrazoline derivatives (5). The final product was found to be highly unstable.

Why do you think this idea will work? Pyrazoline derivatives show good anti-inflammatory activity
Do you have any experimental proof? No
Literature reference
Where it is useful? Useful in reducing inflammation
Do you plan to work on this idea in near future? No
Interested in collaboration? No
Nature of idea:
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