Publishchemidea, 2022 No: 27

Submitted: Monday, December 19th, 2022

Title of the idea: Trimethylorthoacetate as Acid activating reagent
Author of the idea: Ramesha
Email of the author
Key words for search: Carboxylicacid, Orthoester, amide
Explain briefly the idea

Carboxylic acid on reacting with triethylorthoacetate, will form an interesting, very active intermediate. Which can react with any nucleophile to get respective product

Why do you think this idea will work? Carboxylic acid group becomes very active
Do you have any experimental proof? No
Literature reference No
Where it is useful? In peptide synthesis and any other amide formation
Do you plan to work on this idea in near future? No
Interested in collaboration? No
Nature of idea: Both academic and Industrial
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